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  • Title: Guanidinophenyl derivatives of pyrazole: synthesis and inhibitory effect on serine proteinases, blood coagulation and platelet aggregation.
    Author: Ferroni R, Menegatti E, Scalia S, Orlandini P, Guarneri M, Taddeo U.
    Journal: Farmaco Sci; 1986 Oct; 41(10):747-57. PubMed ID: 3539635.
    Abstract:
    Guanidinophenyl derivatives of pyrazole have been synthesized. Their inhibitory effects on (i) bovine trypsin, bovine thrombin, porcine pancreatic kallikrein catalyzed hydrolysis of p-nitro anilide of N alpha -benzoyl-arginine and (ii) blood coagulation and platelet aggregation, were investigated. The kinetic behaviour of all compounds conformed to that of a reversible competitive inhibition pattern, and they were also found to act in vitro as inhibitors of platelet aggregation induced by ADP.
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