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  • Title: Clinical results of immunoscintigraphy in a variety of malignant tumors with special reference to immunohistochemistry.
    Author: Biersack HJ, Bockisch A, Oehr P, Knoblich A, Hartlapp J, Biltz H, Jaeger N, Bellmann O, Vogel J, Björklund B.
    Journal: Nuklearmedizin; 1986 Oct; 25(5):167-71. PubMed ID: 3540857.
    Abstract:
    Radioimmunoscintigraphy was performed in 52 patients with a variety of malignant tumors (colorectal, melanoma, lung, testicular, ovarian, bladder, carcinoid). Respective antibodies or their F(ab')2 fragments against CEA (n = 23), melanoma antigen 225.28 S (n = 18), TPA (n = 4), beta HCG (n = 5) and HMFG2 (n = 2) were selected by immunohistochemistry of the primary tumor. Most patients were suspected of recurrence or of hitherto unknown distant or local metastases. Overall accuracy was 61% (32/52). False negatives amounted to 33% (17/52). Useful additional clinical information-not available by CT, ultrasonics or serum levels of tumor markers-was obtained in 17 out of 52 patients (= 33%). From these results it seems obvious that antibodies used for radioimmunoscintigraphy should be selected on the basis of immunohistochemistry.
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