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  • Title: Bioactive Terphenyls Isolated from the Antarctic Lichen Stereocaulon alpinum.
    Author: Phi KH, Shin MJ, Lee S, So JE, Kim JH, Suh SS, Koo MH, Shin SC, Kim JH, Lee JH, Youn UJ.
    Journal: Molecules; 2022 Apr 06; 27(7):. PubMed ID: 35408757.
    Abstract:
    Three p-terphenyls (2-4)-2-hydroxy-3,5-dimethoxy-p-terphenyl (2), 2-hydroxy-3,6-dimethoxy-p-terphenyl (3), and 2,3,5,6-tetramethoxy-p-terphenyl (4)-were isolated for the first time as natural products along with seven known compounds (1, 5-10) from the Antarctic lichen Stereocaulon alpinum. Structures of the new compounds were elucidated by comprehensive analyses of 1D and 2D NMR and HREIMS experiments. Compound 3 exhibited cytotoxicity against HCT116 cells with the IC50 value of 3.76 ± 0.03 μM and also inhibited NO production in LPS-induced RAW264.7 macrophages with the IC50 value of 22.82 ± 0.015 μM.
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