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  • Title: Cobalt(III)-Catalyzed Regio- and Chemoselective [4 + 2]-Annulation of N-Chlorobenzamides/Acrylamides with 1,3-Dienes at Room Temperature.
    Author: Ramesh B, Jeganmohan M.
    Journal: J Org Chem; 2022 May 06; 87(9):5713-5729. PubMed ID: 35414174.
    Abstract:
    Co(III)-catalyzed regio- and chemoselective redox-neutral C-H annulation of arylamides/acrylamides with 1,3-dienes is described. The present annulation reaction was well suited with a less-reactive 1,3-butadiene. By employing this protocol, pharmaceutically important 3,4-dihydroisoquinolinones were synthesized in good yields. Furthermore, the prepared 3,4-dihydroisoquinolinones were converted into highly important oxirane derivatives in good yields. A plausible mechanistic cycle is proposed and supported by a competition experiment and kinetic isotopic effect (KIE) studies.
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