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  • Title: Monoclonal antibody against bacterial lipopolysaccharide cross-reacts with DNA-histone.
    Author: Sumazaki R, Fujita T, Kabashima T, Nishikaku F, Koyama A, Shibasaki M, Takita H.
    Journal: Clin Exp Immunol; 1986 Oct; 66(1):103-10. PubMed ID: 3542315.
    Abstract:
    Monoclonal antibodies to bacterial lipopolysaccharide (LPS) were prepared by fusing spleen cells from BALB/c mice immunized with Salmonella Minnesota Re 595 LPS to the mouse myeloma cell line P3U1. One of them, designated RS01, revealed a strong positive antinuclear activity and reacted with DNA-histone. RS01 also bound specifically to Salmonella Minnesota Re 595 LPS and eliminated the biological activity of LPS. The Salmonella completely inhibited the ANA activity of RS01 and DNA-histone blocked the reactivity of RS01 with LPS. Thus, it is clear that an anti-LPS monoclonal antibody, RS01 cross-reacts with DNA-histone.
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