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  • Title: Separation of Legionella pneumophila proteases and purification of a protease which produces lesions like those of Legionnaires' disease in guinea pig lung.
    Author: Conlan JW, Baskerville A, Ashworth LA.
    Journal: J Gen Microbiol; 1986 Jun; 132(6):1565-74. PubMed ID: 3543209.
    Abstract:
    Six discrete protease activities were recovered from the supernatant broth of Legionella pneumophila cultures by ion-exchange chromatography. One of these demonstrated in vitro activity against collagen, casein and gelatin. When administered into the lungs of guinea-pigs this protease elicited lesions which were pathologically similar to those seen in clinical and experimentally induced Legionnaires' disease.
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