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  • Title: Cell diversification within the myogenic lineage: in vitro generation of two types of myoblasts from a single myogenic progenitor cell.
    Author: Schafer DA, Miller JB, Stockdale FE.
    Journal: Cell; 1987 Feb 27; 48(4):659-70. PubMed ID: 3545495.
    Abstract:
    We show that a single myogenic progenitor cell in vitro generates two types of myoblasts committed to two distinct myogenic cell lineages. Using fast and slow myosin heavy chain isoform content to define myotube type, we found that myogenic cells from fetal quail (day 10 in ovo) formed two types of myotubes in vitro: fast and mixed fast/slow. Clonal analysis showed that these two types of myotubes were formed from two types of myoblasts committed to distinct fast and fast/slow lineages. Serial subcloning demonstrated that the initial myoblast progeny of an individual myogenic progenitor cell were in the fast lineage, whereas later progeny were in the fast/slow lineage. Fast and slow myosin expression within particular myotubes reflects the genetic processes underlying myoblast commitment to diverse myogenic lineages.
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