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  • Title: Electronic considerations in the mutagenesis of some 4,5-bridged chrysenes.
    Author: Lee-Ruff E, Raj AS, Kruk H, Katz M.
    Journal: Environ Mutagen; 1987; 9(2):183-9. PubMed ID: 3545800.
    Abstract:
    The mutagenic activity of four 4,5-bridged chrysene derivatives, benz(a)aceanthrylene, and 5-methylchrysene was examined using histidine auxotrophic strains TA98 and TA100 of Salmonella typhimurium. All compounds showed a positive mutagenic response with both TA100 and TA98 in the presence of S-9. A correlation between the electronic character of the bridging group and mutagenic activity for the chrysene derivatives is proposed.
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