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  • Title: Central neural control of pineal melatonin synthesis in the rat.
    Author: Møller M, Reuss S, Olcese J, Stehle J, Vollrath L.
    Journal: Experientia; 1987 Feb 15; 43(2):186-8. PubMed ID: 3545893.
    Abstract:
    To investigate a possible central neural influence on nocturnal pineal metabolic activity in rats, frontal transsections of the stria medullaris thalami were conducted. Enzymes involved in melatonin synthesis, i.e. N-acetyltransferase and hydroxyindole-O-methyl-transferase, exhibited reduced activities in operated animals when compared to controls. These results indicate a modulatory role of central structures on nocturnal pineal indole metabolism.
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