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  • Title: PIMT/TGS1: An evolving metabolic molecular switch with conserved methyl transferase activity.
    Author: Edwin RK, Challa N, Sharma R, Satyamoorthy K, Parsa K, Misra P.
    Journal: Drug Discov Today; 2022 Aug; 27(8):2386-2393. PubMed ID: 35462043.
    Abstract:
    Transcriptional coactivators play a crucial role in regulating gene expression. PRIP interacting protein with methyl transferase domain (PIMT)/trimethyl guanosine synthase 1 (TGS1) is a co-activator interacting protein with an RNA methyl transferase domain. PIMT serves as a bridge between HAT and non-HAT coactivators and differentially modulates gene expression. Disruption of PIMT is embryonic lethal. PIMT regulates hepatic gluconeogenesis and TNF-α-induced insulin resistance in the skeletal muscle. As a methyl transferase, PIMT controls post-transcriptional regulation of HIV-1 and is essential for human telomerase RNA biogenesis. This review comprehensively describes the dual role of PIMT, which promises to be a putative target in metabolic disorders.
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