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  • Title: Induction of antitumor resistance to mouse leukemia L1210 by spergualins.
    Author: Ishizuka M, Masuda T, Mizutani S, Osono M, Kumagai H, Takeuchi T, Umezawa H.
    Journal: J Antibiot (Tokyo); 1986 Dec; 39(12):1736-43. PubMed ID: 3546237.
    Abstract:
    Spergualin and its analog, 15-deoxyspergualin showed a marked antitumor effect against L1210 by intraperitoneal and oral administrations. After treatment with these substances 40- or 60-day survivors (cured mice of L1210) were resistant to reinoculation of L1210 cells. They were resistant only to L1210. The antitumor effector cells in these mice were determined to be T cells. NK activity of spleen cells was also enhanced by spergualins. The antitumor activity of 15-deoxyspergualin was markedly reduced in immuno-deficient mice. IL (interleukin)-2 production, but not IL-1, was enhanced in supernatant of mixed lymphocyte cultures by treatment with 15-deoxyspergualin. The mechanism of action of 15-deoxyspergualin on the immune system was discussed.
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