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  • Title: Localization of interleukin-1 in normal or reactive lymphoid tissues and skin: abundance of IL-1 in interdigitating reticulum cells.
    Author: Hsu SM, Zhao X.
    Journal: Lymphokine Res; 1987; 6(1):13-8. PubMed ID: 3546961.
    Abstract:
    The distribution of interleukin 1 producing cells was determined in the human lymphoid tissues and skin using immunohistochemical staining and a rabbit anti-interleukin-1 antibody. Interleukin-1 was detected mainly in the interdigitating reticulum cells localized in the T cell zone. Approximately, 10-30% of the histiocytes were also positively stained by anti-interleukin-1. The results suggests that interdigitating reticulum cells may play an important role in the initiation and amplification of T-cell immunity.
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