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Title: Prophylactic co-trimoxazole in biliary surgery. Author: Morran C, McNaught W, McArdle CS. Journal: Br Med J; 1978 Aug 12; 2(6135):462-4. PubMed ID: 354746. Abstract: A double-blind study was conducted to test the prophylactic effect of a single dose of co-trimoxazole on the incidence of septic complications after elective cholecystectomy. Forty-eight patients received co-trimoxazole and 47 placebo. Wound sepsis occurred in 10 (21%) of the controls but in only 2 (4%) of the treated group, and the incidences of pulmonary complications were 49% (23 cases) and 19% (9) respectively. These differences were significnat. Wound sepsis after cholecystectomy occurs mostly in patients with infected bile. Co-trimoxazole given by intravenous infusion rapidly achieves a high concentration in the palsma and is effective against most biliary pathogens.[Abstract] [Full Text] [Related] [New Search]