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  • Title: A review of the role of beta-lactamase-producing bacteria in obstetric-gynecologic infections.
    Author: Eschenbach DA.
    Journal: Am J Obstet Gynecol; 1987 Feb; 156(2):495-503. PubMed ID: 3548377.
    Abstract:
    beta-Lactam antibiotics are the most commonly used antibiotics in obstetrics and gynecology. However, they are susceptible to inactivation when attacked by beta-lactamase, an enzyme produced by many bacterial species. During the past three decades, numerous penicillins and cephalosporins have been made with a stable beta-lactam ring that resists enzyme attack. More recently enzyme inhibitors have been discovered that inactivate beta-lactamase. The combination of an enzyme inhibitor with a beta-lactam antibiotic, such as ampicillin, restores the antimicrobial activity of the beta-lactam against formerly resistant strains of staphylococci, Haemophilus influenzae, Enterobacteriaceae, and Bacteroides fragilis.
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