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  • Title: Automated synthesis of (R)-[18 F]MH.MZ on the iPhase Flexlab reaction platform.
    Author: Rosenberg AJ, Cheung YY, Liu F, Peterson TE, Silverman J, Considine CM, Claassen DO.
    Journal: J Labelled Comp Radiopharm; 2022 Jun 30; 65(8):223-229. PubMed ID: 35491085.
    Abstract:
    (R)-[18 F]MH.MZ ([18 F]MH.MZ) is a promising positron emission tomography (PET) radiotracer for in vivo study of the 5-HT2A receptor. To facilitate clinical trials, a fully automated radiosynthesis procedure for [18 F]MH.MZ was developed using commercially available materials on the iPhase Flexlab module. The overall synthesis time was 100 min with a radiochemical yield of 7 ± 0.9% (n = 3). The radiochemical purity was greater than 99% for [18 F]MH.MZ with a molar activity of 361 ± 57 GBq/μmol (n = 3). The protocol described herein reliably provides [18 F]MH.MZ that meets all relevant release criteria for a GMP radiopharmaceutical.
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