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Pubmed for Handhelds

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  • Title: Insulin causes insulin-receptor internalization in human erythrocyte ghosts.
    Author: Kelleher RS, Murray EF, Peterson SW.
    Journal: Biochem J; 1987 Jan 01; 241(1):93-7. PubMed ID: 3551928.
    Abstract:
    The effect of incubation with insulin on insulin-receptor internalization by erythrocyte ghosts was investigated. The number of surface insulin receptors decreased by 30-40% after incubation of ghosts with insulin. Total insulin-receptor binding to solubilized ghosts was the same in insulin-incubated and control ghosts, whereas insulin binding to an internal vesicular fraction was substantially increased in insulin-incubated ghosts. Our findings suggest that erythrocyte-ghost insulin receptors are internalized to a vesicular compartment in response to incubation with insulin.
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