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  • Title: Amiloride with or without salbutamol versus placebo: effects on lipoproteins in hypertensive patients treated with timolol-hydrochlorothiazide.
    Author: Spence JD, Wong DG.
    Journal: J Hypertens Suppl; 1986 Dec; 4(5):S515-8. PubMed ID: 3553482.
    Abstract:
    Because thiazides and beta-blockers have adverse effects on lipoproteins, while magnesium repletion (shown to occur with amiloride) and beta 2 agonists improve lipids, we studied the effects of 3 months each of amiloride with and without salbutamol with and without placebo in a 2 X 2 factorial crossover study in which all patients took timolol-hydrochlorothiazide twice daily for 1 year. A total of 118 subjects entered, and 97 patients completed all four crossovers of amiloride + salbutamol, amiloride + placebo, salbutamol + placebo and placebo + placebo. No significant differences were seen among the four study regimens with respect to blood pressure, total cholesterol, triglycerides or high-density lipoproteins (HDL). The study power was 99% for total cholesterol, 46% for triglycerides and 93% for HDL. Timolol-hydrochlorothiazide had no significant effect, suggesting that the use of such drugs to offset the adverse effects of antihypertensive drugs on lipoproteins is not effective; the selection of alternative antihypertensive agents appears to be a preferable strategy.
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