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  • Title: Enhancement of amyloid induction by amyloid fibril fragments in hamster.
    Author: Niewold TA, Hol PR, van Andel AC, Lutz ET, Gruys E.
    Journal: Lab Invest; 1987 May; 56(5):544-9. PubMed ID: 3553738.
    Abstract:
    An extract (fibril amyloid-enhancing factor) prepared by sonication of a suspension of water-purified hamster AA-amyloid fibrils showed an amyloid-enhancing effect upon intraperitoneal injection into hamsters. The fibril amyloid-enhancing factor was identical to the original fibrils according to the results of infrared spectroscopy, gel filtration, gel electrophoresis, and Western blotting; although lyophilized samples of the extract did not show any green birefringence after staining with Congo red. From these results, it was concluded that fibril amyloid-enhancing factor represents small fragments of amyloid fibrils which enhance in vivo formation of amyloid fibrils.
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