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  • Title: Recombinant vaccinia virus LC16m0 or LC16m8 that expresses hepatitis B surface antigen while preserving the attenuation of the parental virus strain.
    Author: Morita M, Suzuki K, Yasuda A, Kojima A, Sugimoto M, Watanabe K, Kobayashi H, Kajima K, Hashizume S.
    Journal: Vaccine; 1987 Mar; 5(1):65-70. PubMed ID: 3554809.
    Abstract:
    Thymidine kinase-negative recombinant vaccinia virus LC16m0 or LC16m8 expressing hepatitis B surface antigen preserved almost the same pathogenicity as their parental thymidine kinase-positive attenuated virus strains. The results demonstrate the potential for using the LC16m0 or LC16m8 virus strain as a vector for recombinant vaccine.
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