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  • Title: Single-dose antimicrobial therapy in the treatment of asymptomatic bacteriuria in pregnancy.
    Author: Jakobi P, Neiger R, Merzbach D, Paldi E.
    Journal: Am J Obstet Gynecol; 1987 May; 156(5):1148-52. PubMed ID: 3555088.
    Abstract:
    Fifty obstetric patients with asymptomatic bacteriuria were treated by single-dose antimicrobial therapy. The immediate cure rate was 84% and the recurrence rate was 12%. Seven of the eight patients in whom single-dose treatment failed responded to subsequent 7-day therapy with the same drug, indicating renal involvement. A 50% recurrence rate in the group of patients in whom single-dose treatment failed was compared with a 5% recurrence rate in the group cured by single-dose therapy, which indicates that failure with single-dose antimicrobial therapy can serve as a therapeutic test to identify patients at high risk for recurrent bacteriuria and its sequelae during pregnancy. It is concluded that single-dose antimicrobial therapy is a safe and effective way to treat asymptomatic bacteriuria in pregnant patients without urologic problems in their history.
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