These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [In vitro effects of E. coli endotoxin on the membrane permeability and substrate transport of isolated rat liver mitochondria].
    Author: Kopprasch S, Hörkner U, Knauth H, Orlik H, Scheuch DW.
    Journal: Biomed Biochim Acta; 1987; 46(1):59-66. PubMed ID: 3555480.
    Abstract:
    Incubation of freshly isolated rat liver mitochondria with E. coli endotoxin resulted in an increased inner membrane permeability for K+ and Cl- ions. This effect was not prevented by addition of the synthetic antioxidant butylated hydroxytoluene. The carrier-mediated transport rates of phosphate, pyruvate, citrate and reducing equivalents via the malate-aspartate shuttle were not altered significantly by endotoxin. Therefore, the endotoxin-mediated impairment of mitochondrial respiration and oxidative phosphorylation could not be attributed to a decrease in transport capacities through the inner mitochondrial membrane.
    [Abstract] [Full Text] [Related] [New Search]