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  • Title: Anti-platelet opsonic activity in alloimmune and autoimmune thrombocytopenia.
    Author: Lucas GF, Hadley AG, Holburn AM.
    Journal: Clin Lab Haematol; 1987; 9(1):59-66. PubMed ID: 3555971.
    Abstract:
    A chemiluminescence technique (CLT) has been developed which measures the interaction between human monocytes and antibody-coated (opsonized) platelets. This technique has an objective end-point, is simple to perform and is of comparable sensitivity to the platelet suspension immunofluorescence test (PSIFT) when used to detect anti-platelet allo-antibodies. In contrast, only 4/20 sera from patients with clinically diagnosed autoimmune thrombocytopenia were opsonic in the CLT, while 8/20 of these same sera bound IgG to platelets in the PSIFT. Only one serum gave positive results in both tests.
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