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  • Title: Influence of antisera to pancreatic acinar cells on rat pancreas in situ.
    Author: Letko G, Spormann H, Sokolowski A, Burger P.
    Journal: Dtsch Z Verdau Stoffwechselkr; 1987; 47(1):26-32. PubMed ID: 3556141.
    Abstract:
    For investigations of cell injury during pathogenesis of acute pancreatitis antisera to pancreatic acinar cells were used as experimental tool. Within one hour after intraductal injection of antiserum a strong pancreatic edema was developed. Within 24 h this edema receded to a large extent but at this time there were inflammatory cells scattered in the intra- and periductal region. As a sequel of application of antiserum pancreatic enzymes were released. At 24 h after this application serum activities of alpha-amylase and lipase were significantly increased in comparison to the control and reached that level which was found in a model of acute pancreatitis provoked by pancreatic edema plus short-term ischemia.
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