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  • Title: Molecular interaction of nonsteroidal compounds with uterine progesterone receptor (Part I).
    Author: Agnihotri A, Neelima, Niwas S, Bhat BK, Kumar S, Seth M, Bhaduri AP, Srivastava AK, Kamboj VP.
    Journal: Exp Clin Endocrinol; 1986 Dec; 88(2):185-92. PubMed ID: 3556407.
    Abstract:
    Progesterone-receptor binding affinity of some nonsteroidal molecules was assessed by competitive protein binding assay in rabbit as well as human uterine cytosol in vitro. Of 40 compounds belonging to 5 different series tested, 3-(p-anisoyl)-2-chloro-6, 7-dimethoxy-quinoline exhibited around 50% inhibition whereas 2-(p-anisoyl) naphthalene and 3-substituted phenyl-1-(3-(2-chloro-6, 7-dialkoxy) quinolinyl)prop-2-en-1-one showed around 20% inhibition in 3H-progesterone binding for rabbit and human uterine progesterone receptor.
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