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  • Title: [Pharmacological effects of combinations of psychotropic preparations used in combined pharmacotherapy].
    Author: Zimakova IE, Baĭchurina AZ, Zimakov IuA.
    Journal: Farmakol Toksikol; 1987; 50(1):8-10. PubMed ID: 3556558.
    Abstract:
    It was shown in experiments on mice that inhibition of the exploratory activity by ftoracizin, phenazepam, scopolamine hydrobromide and their combinations predominates in comparison with muscle relaxation. Phenazepam administered at the low dose (0.025 mg/kg) by its depressive effect on the central nervous system was an antagonist of ftoracizin and a synergist of scopolamine. Ftoracizin and scopolamine show a mutual dose-effects-dependent antagonism in the inhibitory action and acute toxicity (LD50).
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