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  • Title: Cellular schwannoma: a distinct pseudosarcomatous entity.
    Author: Fletcher CD, Davies SE, McKee PH.
    Journal: Histopathology; 1987 Jan; 11(1):21-35. PubMed ID: 3557324.
    Abstract:
    Eighteen cases of cellular schwannoma, a recently delineated benign entity, are described. These tumours present most often in middle-aged adults of either sex and show a predilection for the paravertebral region of the mediastinum and retroperitoneum. More than half the tumours macroscopically arose from a nerve but none was associated with von Recklinghausen's disease. The light microscopic features are remarkably consistent but are not immediately recognizable as neural in type. Means of distinction from a malignant nerve sheath tumour and from a variety of other soft tissue tumours are discussed. Immunohistochemical positivity for S-100 protein has been demonstrated in 17 of the 18 cases. Prolonged follow-up has revealed local recurrence in only one case; none has metastasized.
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