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  • Title: GABA transaminase provides an alternative route of beta-alanine synthesis in Aspergillus nidulans.
    Author: Arst HN.
    Journal: Mol Gen Genet; 1978 Jul 06; 163(1):23-7. PubMed ID: 355840.
    Abstract:
    Three unlinked genes where mutation can lead to D(+)-pantothenic acid auxotrophy in Aspergillus nidulans have been identified. pantoA is probably the structural gene for pantothenate synthetase (EC 6.3.2.1) whilst pantoB and pantoC are involved in the syntheses of D-pantoic acid and beta-alanine, respectively. A pantoC- mutant is tentatively considered to be blocked in conversion of 5,6-dihydrouracil to beta-ureidopropionate. An alternative route of beta-alanine biosynthesis occurs by the transamination of malonic semialdehyde, catalysed by GABA transaminase. The possibility that beta-alanine can be replaced by certain structurally related compounds and yet nevertheless yield biologically active coenzyme A analogues is discussed.
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