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  • Title: The calibration of rabbit tissue thromboplastins: experience of the Dutch Reference Laboratory for anticoagulant control.
    Author: van den Besselaar AM, Hermans J, van der Velde EA, Bussemaker-Verduyn den Boer E, van Halem-Visser LP, Jansen-Grüter R, Loeliger EA.
    Journal: J Biol Stand; 1986 Oct; 14(4):305-17. PubMed ID: 3558415.
    Abstract:
    A number of commercial rabbit tissue thromboplastins used in oral anticoagulant control have been calibrated against the first International Reference Preparation for thromboplastins. This was done in a three-stage procedure by one laboratory, each stage representing a different level of thromboplastin comparability. The calibration model recently recommended by ICTH and ICSH was tested. This model proved to be suitable, although a statistically significant aberration was observed for some of the thromboplastins. The bias introduced by using the model in these non-ideal cases was small compared to the overall variation of the International Normalized Ratio, being the universal scale for reporting the prothrombin time during oral anticoagulant control. Batch-to-batch calibration using lyophilized pooled plasmas could be reliably performed for several commercial thromboplastins.
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