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Title: Histogram Analysis of Apparent Diffusion Coefficient on Diffusion Weighted Magnetic Resonance Imaging in Differentiation between Low and High Grade Serous Ovarian Cancer. Author: Liu X, Wang T, Wang Y, Wang J, Jin J, Zhang G, Zhang H. Journal: Curr Med Imaging; 2023; 19(2):167-174. PubMed ID: 35585829. Abstract: BACKGROUND: Ovarian cancer is a leading cause of death in gynecological malignancies. Being the most common subtype in OEC, ovarian serous cancer also includes two subtypes: low grade serous ovarian cancer (LGSC) and high grade serous ovarian cancer (HGSC) (1). PURPOSE: The study aims to assess the capability of apparent diffusion coefficient (ADC) histogram analysis and conventional measurements on magnetic resonance imaging (MRI) in differentiating between LGSC and HGSC. METHODS: We retrospectively recruited 38 patients with pathologically proven ovarian serous epithelial cancer. The mean ADC value was measured by one technician using two methods on post-processed workstation. The ADC value and histogram parameter difference between LGSC and HGSC groups were compared. The correlation between the ADC value and the Ki-67 expression was calculated across both groups. RESULTS: The repeatability of ADC measurements across two methods was good; the ROI method (ADC-roi) had better performance repeatability than the area method (ADC-area). The value of ADC-mean , ADC-min, ADC-max, and ADC-area significantly differed between both groups (p < 0.001). The value of ADC-area correlated inversely with ki-67 expression in the whole group (Pearson coefficient = -0.382, p = 0.02). The 3D computerized-diagnostic model had the best discriminative performance in determining HGSC than 2D and conventional ADC measurements. The 3D model yielded a sensitivity of 100%, a specificity of 95.45%, and an accuracy of 97.73%. CONCLUSION: In the present study, the 3D ADC histogram model help differentiate HGSC from LGSC with a better performance than conventional ADC measurements.[Abstract] [Full Text] [Related] [New Search]