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  • Title: Cerebral arteriovenous malformations, steal, and the hypertensive breakthrough threshold. An experimental study in rats.
    Author: Morgan MK, Johnston I, Besser M, Baines D.
    Journal: J Neurosurg; 1987 Apr; 66(4):563-7. PubMed ID: 3559722.
    Abstract:
    An experiment was designed to investigate the effects of arteriovenous (AV) fistula occlusion on cerebral autoregulation. A right carotid-jugular fistula was created in 63 rats in such a way as to produce an intracranial AV fistula with a loop extension into the neck. The fistula was occluded after an 8-week interval with the rats under both normotension and metaraminol-induced hypertension, and evidence of blood-brain barrier disruption was investigated with an Evans blue dye technique. The results indicate that an intracranial AV fistula may cause cerebral steal which is responsible for a reduction in the threshold for hypertensive breakthrough following fistula occlusion.
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