These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Lowering of plasma isoxicam concentrations with acetylsalicylic acid.
    Author: Grace EM, Mewa AA, Sweeney GD, Rosenfeld JM, Darke AC, Buchanan WW.
    Journal: J Rheumatol; 1986 Dec; 13(6):1119-21. PubMed ID: 3560102.
    Abstract:
    The pharmacokinetics of isoxicam 200 mg administered orally in 10 healthy male volunteers was studied before and during administration of acetylsalicylic acid 3.9 g daily by mouth starting 5 days after isoxicam. There was a statistically significant decrease in plasma isoxicam concentrations, but no significant change in time to reach maximum plasma concentration or disappearance time. The mechanisms of this interaction is probably competitive displacement of isoxicam from albumin by acetylsalicylic acid or salicylate. These results are consistent with the known effect of ASA in producing competitive displacement of other protein bound antiinflammatory drugs.
    [Abstract] [Full Text] [Related] [New Search]