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Title: ATP-induced conformational changes in the restriction endonuclease from Escherichia coli K-12. Author: Bickle TA, Brack C, Yuan R. Journal: Proc Natl Acad Sci U S A; 1978 Jul; 75(7):3099-103. PubMed ID: 356045. Abstract: ATP induces a conformational change in the Escherichia coli K-12 restriction enzyme that allows it to discriminate between unmodified and modified DNA recognition sequences. This conformational change does not require ATP hydrolysis. However, ATP hydrolysis is a requirement for DNA cleavage.[Abstract] [Full Text] [Related] [New Search]