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  • Title: Methods for Direct Reductive N-Methylation of Nitro Compounds.
    Author: Jiang Z, Mahmood EA, Harofteh NZ, Ebadi AG, Toughani M, Vessally E.
    Journal: Top Curr Chem (Cham); 2022 May 24; 380(4):27. PubMed ID: 35606628.
    Abstract:
    Direct reductive N-methylation of inexpensive and readily available nitro compounds as raw material feedstocks is more attractive and straightforward compared with conventional N-methylation of amines to prepare biologically and pharmaceutically important N-methylated amine derivatives. This strategy for synthesis of N-methylamines avoids prepreparation of NH-free amines and therefore significantly shortens the separation and purification steps. In recent years, numerous methylating agents and catalytic systems have been reported for this appealing transformation. Thus, it is an appropriate time to summarize such advances. This review elaborates on the most important discoveries and advances in this research arena, with special emphasis on the mechanistic aspect of reactions that may provide new insights into catalyst improvement.
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