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  • Title: Total Synthesis of (-)-Bastimolide A: A Showcase for Type I Anion Relay Chemistry.
    Author: Cox JB, Kellum AA, Zhang Y, Li B, Smith AB.
    Journal: Angew Chem Int Ed Engl; 2022 Jul 11; 61(28):e202204884. PubMed ID: 35608327.
    Abstract:
    A highly convergent total synthesis of (-)-bastimolide A (1), a polyhydroxy antimalarial macrolide, has been achieved via a longest linear sequence of twenty steps from commercially available glycidyl ethers. Type I Anion Relay Chemistry (ARC) coupling tactics enable rapid construction of the molecule's 1,5-polylol backbone. A late-stage B-alkyl Suzuki-Miyaura union and an Evans-modified Mukaiyama macrolactonization generate the forty-membered Z-α,β-unsaturated macrocyclic lactone.
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