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  • Title: Anti-immunoglobulin antibody detection in adjuvant arthritis by an ELISA technique.
    Author: Castell M, Castellote MC, Queralt J.
    Journal: Pathol Res Pract; 1986 Dec; 181(6):664-7. PubMed ID: 3562339.
    Abstract:
    Sprague-Dawley rats, injected in the hind paw with heat-killed mycobacteria dispersed in oil, develop a severe polyarthritis. In this paper, we detected and quantified by a micro-ELISA technique autoantibodies against immunoglobulins in rats with adjuvant arthritis. Increased total anti-immunoglobulin antibodies levels were found from 3 days after induction and remained elevated until day 42. IgG anti-immunoglobulin antibodies in arthritic animals were significantly elevated during days 35-42. These results show that alterations in the humoral immune response (synthesis of anti-immunoglobulin antibodies) are present in adjuvant arthritis as they are in human rheumatoid arthritis.
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