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  • Title: Avoidance facilitation in adult mice by prenatal administration of the nootropic drug oxiracetam.
    Author: Ammassari-Teule M, D'Amato FR, Sansone M, Oliverio A.
    Journal: Pharmacol Res Commun; 1986 Dec; 18(12):1169-76. PubMed ID: 3562507.
    Abstract:
    CD-1 mice prenatally exposed to saline solution or to the nootropic drug oxiracetam (50 mg/kg during the whole pregnancy) were tested, when adults, for locomotor activity and for shuttle-box avoidance acquisition. Prenatal drug exposure produced long-lasting effects, evident in mature offspring. At the age of two months, mice prenatally exposed to oxiracetam showed a slight but significant reduction in locomotor activity. At the age of three months, these animals exhibited higher performances than control mice in avoidance acquisition.
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