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  • Title: Rapid sensing and imaging of methylglyoxal in living cells enabled by a near-infrared fluorescent probe.
    Author: Xu H, Liu XR, Cai ZH, Zheng J, Wang YW, Peng Y.
    Journal: Org Biomol Chem; 2022 Jun 15; 20(23):4782-4786. PubMed ID: 35635197.
    Abstract:
    A novel near-infrared fluorescent probe (SWJT-2) has been designed and synthesized for the detection of methylglyoxal (MGO). It showed a low detection limit (0.32 μM), high selectivity and the fastest detection (15 min) over various reactive carbonyl compounds in aqueous solution. SWJT-2 had been successfully applied to bioimaging in HeLa cells to detect exogenous and endogenous MGO.
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