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  • Title: Gastrointestinal stromal tumor in the fourth portion of the duodenum does not express the CD117: A case report.
    Author: Harhar M, Harouachi A, Akouh N, Atmani A, Aabdi H, Bouhout T, Bennani A, Serji B, El Harroudi T.
    Journal: Ann Med Surg (Lond); 2022 May; 77():103560. PubMed ID: 35637997.
    Abstract:
    INTRODUCTION: Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the digestive tract. PRESENTATION OF CASE: 54-year-old woman with a history of phyllodes tumor of the left breast he patient was admitted to our hospital for management of retroperitoneal soft tissue tumor, attached to the fourth portion of the duodenum, opposite the head of the pancreas. The patient underwent a large excision of the tumor, the duodenojejunal flexure, and the third and fourth portions of the duodenum along with the head of the pancreas. The histopathological examination confirmed the presence of a spindlecell mesenchymal proliferation. These cells do not express CD117, but they express DOG1. A PDGFRA mutation was identified later. The final diagnosis was duodenal GIST. DISCUSSION: few cases of GIST in the fourth portion of the duodenum had been reported in the literature. PDGFRA mutation is identified as GISTs tumorigenesis to 15% of cases, and the diagnosis of GISTs is not based solely on the expression of the protein Kit. CONCLUSION: the molecular biology examinations are very helpful in the direction of the correct diagnosis in case of negative staining for CD117.
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