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  • Title: Nickel-Catalyzed Reductive Coupling of γ-Metalated Ketones with Unactivated Alkyl Bromides.
    Author: Cui N, Lin T, Wang YE, Wu J, Han Y, Xu X, Xue F, Xiong D, Walsh PJ, Mao J.
    Journal: Org Lett; 2022 Jun 10; 24(22):3987-3992. PubMed ID: 35639094.
    Abstract:
    A nickel-catalyzed reductive cross-coupling reaction of aryl cyclopropyl ketones with easily accessible unactivated alkyl bromides to access aryl alkyl ketones has been developed. This strategy facilitates access to various of γ-alkyl-substituted ketones via ring opening of cyclopropyl ketones (26 examples, 50-90% yield). Initial mechanistic studies revealed that the reaction proceeds via radical cleavage of the alkyl bromide.
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