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  • Title: The binding of ciamexone to globin: its demonstration and some accompanying effects in rats.
    Author: Isert B, Götz G, van der Trenck KT, Friedberg KD.
    Journal: Toxicol Appl Pharmacol; 1987 Mar 15; 87(3):490-7. PubMed ID: 3564022.
    Abstract:
    The 2-cyanaziridines Ciamexone and Azimexone in doses of 100 and 500 mg/kg lead to a reversible dose-dependent formation of thermolabile hemoglobin and Heinz bodies, a lowered erythrocyte count, and splenomegaly. According to our investigations these effects may have been caused by a covalent binding of the 2-cyanaziridines or their metabolites to globin in the erythrocytes. This binding was shown by gel electrophoresis using 14C-labeled Ciamexone. The change of the globin had no influence on the oxygen affinity of the hemoglobin.
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