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  • Title: Diurnal variations in folacin levels of human milk: use of a single sample to represent folacin concentration in milk during a 24-h period.
    Author: Udipi SA, Kirksey A, Roepke JL.
    Journal: Am J Clin Nutr; 1987 Apr; 45(4):770-9. PubMed ID: 3565305.
    Abstract:
    Studies of breast-feeding and its adequacy for the infant could be simplified if a single milk sample were representative of nutrient levels during a 24-h period, despite diurnal variation. In this study, free and total folacin levels were measured in samples collected from 27 well-nourished mothers at each infant feeding from 2 wk to 1 yr of lactation. Folacin levels were higher (p less than 0.05) in the afternoon and evening than in the morning; variations decreased as lactation progressed (greater than 8 mo) and paralleled the decreased number of daily feedings. Despite 2- to 3-fold variations in milk folacin levels occur a 24-h period during the first 10 mo of lactation, the level in a single sample obtained at 1300-1450 h was representative (r = 0.74-0.93) of mean folacin concentration in samples obtained from all feedings during a 24-h period.
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