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  • Title: Experimental colorectal cancer as a model of human disease.
    Author: Gilbert JM.
    Journal: Ann R Coll Surg Engl; 1987 Mar; 69(2):48-53. PubMed ID: 3566126.
    Abstract:
    Colorectal cancer may now be induced consistently in experimental animals by the carcinogen 1,2-dimethylhydrazine (DMH). Adenomas and adenocarcinomas are produced in the large bowel and these resemble human colorectal cancer both macroscopically, and in their clinical behaviour. They are a close model of human disease and may be used for the evaluation of anti-cancer therapies and for the development of a diagnostic test for colorectal cancer.
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