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  • Title: [Toxicity of rubomycin 13-cyclohexylidene hydrazone].
    Author: Stepanova ES, Vertogradova TP, Shevniuk LA, Shepelevtseva NG, Gol'dberg LE.
    Journal: Antibiot Med Biotekhnol; 1987 Jan; 32(1):42-7. PubMed ID: 3566228.
    Abstract:
    The systemic effect and toxicity of rubomycin 13-cyclohexylidene hydrazone (RCH) were studied in comparison to those of rubomycin on noninbred albino mice. The drugs were used intravenously in single doses or a course consisting of 5 injections. When used intravenously in a single dose RCH was 2 times less toxic than rubomycin. RCH differed from rubomycin by the character of animal death: the former induced death of the animals immediately after its intravenous administration, while with the use of the latter the animals died within the first 5-10 days after the drug injection. When used during the treatment course including 5 intravenous injections in doses of 0.45 or 0.3 of LD50, the inhibitory effects of the drugs on hemopoiesis were similar by their nature, RCH had a more pronounced cardiotoxic effect than rubomycin.
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