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  • Title: [Treatment by prostaglandin E1 of isolated coarctations in newborn infants with acute cardiac failure].
    Author: Sidi D, Duval-Arnould M, Kachaner J, Villain E, Pedroni E, Piéchaud JF.
    Journal: Arch Fr Pediatr; 1987 Jan; 44(1):21-5. PubMed ID: 3566440.
    Abstract:
    In neonates with isolated coarctation of the aorta presenting with acute neonatal heart failure refractory to classical treatment, emergency surgery is associated with a 30% death-rate. We rather suggest to add to treatment a perfusion of prostaglandin E1 in order to dilate the ductus arteriosus and thereby the aortic isthmus. This was performed successfully in 9 of 12 neonates aged 5 to 16 days: coarctation was relieved and heart failure disappeared. As soon as the left ventricle became hyperkinetic again (2 to 6 days later), prostaglandin was discontinued. Coarctation reappeared with either chronic heart failure (3 cases) or severe arterial hypertension (5 cases). Eventually one child recovered without surgery and the other 11 were operated on at an average age of 24 days, with only one death.
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