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  • Title: Toxicity of 2, 2', 4, 4'-tetrabromodiphenyl ether (BDE-47) on the green microalgae Chlorella sp. and the role of cellular oxidative stress.
    Author: Zhao Y, Wang X, Tang X, Zhao Y.
    Journal: Mar Pollut Bull; 2022 Jul; 180():113810. PubMed ID: 35665619.
    Abstract:
    Polybrominated diphenyl ethers (PBDEs) are toxic to marine organisms including the major primary producer phytoplankton, while the toxic mechanisms haven't yet been fully clarified. Therefore, we comprehensively studied the toxic mechanisms of BDE-47 on the marine chlorophyte Chlorella sp., with a focus on the role of cellular oxidative stress. The results indicate that BDE-47 stress resulted in the inhibition of population growth as well as cell death and programmed cell death. The antioxidant system was activated in both low and high BDE-47 treatments, but only microalgal cells in the high BDE-47 treatment showed cellular oxidative stress. By adding ROS inhibitor, the relief of photosynthetic inhibition, Ca2+ overproduction and cell death was found. Therefore, we conclude that photosynthetic damage, cell death and cellular oxidative stress were the major mechanisms of BDE-47 toxicity to Chlorella sp., and that cellular oxidative stress played an important role in mediating the other mechanisms.
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