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  • Title: Oxidative phosphorylation of creatine by respiring pig heart mitochondria in the absence of added adenine nucleotides.
    Author: Kim IH, Lee HJ.
    Journal: Biochem Int; 1987 Jan; 14(1):103-10. PubMed ID: 3566769.
    Abstract:
    Isolated pig heart mitochondria were found to form phosphocreatine continuously at the rate of 12.5 +/- 1.8 nmol per min per mg of the mitochondrial protein in the respiration medium without externally added adenine nucleotides, and its formation rate showed a concentration dependency with respect to creatine and phosphate. The synthesis of phosphocreatine was completely inhibited by antimycin, FCCP (carbonyl cyanide-p-trifluoromethoxyphenylhydrazone), and atractyloside. However, oligomycin had no effect on the rate of phosphocreatine formation. These results are discussed in terms of a model that heart mitochondrial creatine kinase is functionally coupled to the oxidative phosphorylating system via the action of the adenine nucleotide translocase.
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