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  • Title: [Pharmacological effect of exogenous histones on muscles].
    Author: Kharchenko EP, Bagrov AIa, Sokolova TV.
    Journal: Biull Eksp Biol Med; 1987 Apr; 103(4):418-20. PubMed ID: 3567334.
    Abstract:
    Different histone fractions contain sequences homologous to those of several regulatory peptides. All the histone fractions demonstrated dose-dependent positive chronotropic effect in spontaneously contracting rat atrial preparations. The range of their activity was as follows: H4 greater than H1 greater than H2a much greater than H3. Synthetic COOH-terminal histone H4 pentapeptide (historphin) Tyr-Gly-Phe-Gly-Gly demonstrated opioid activity by inhibiting electrostimulated guinea-pig ileal contractions. It is suggested that some biological activities of histones are related to the presence of regulatory peptide sequences in their structure.
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