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  • Title: [Stimulation of the immune response during blockade of serotonin receptors by cyproheptadine].
    Author: Idova GV, Cheĭdo MA.
    Journal: Biull Eksp Biol Med; 1987 Apr; 103(4):440-2. PubMed ID: 3567337.
    Abstract:
    The role of serotonin receptors in the inhibitory effect of serotoninergic system on immunogenesis was studied using cyproheptadine, a specific blocker of 5-HT2 receptors. It was shown that cyproheptadine administration to CBA mice stimulated the immune response, which was dopamine-dependent and was realized via thymus. With the pituitary stalk destruction, the stimulatory effect of cyproheptadine was not observed, which suggests the participation of 5-HT2 brain receptors in immunogenesis.
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