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  • Title: [Vitamin A status and the carcinogenic action of N-nitrosobenzyl methylamine on the esophagus in the rat].
    Author: Nicol M, Daliam A, Cottencin M, Ramée MP, Savouré N.
    Journal: Bull Cancer; 1987; 74(1):3-12. PubMed ID: 3567383.
    Abstract:
    A state of pure vitamin A deficiency, without any clinical manifestations, rapidly induces a stimulation of ornithine decarboxylase (ODC) activity and some oesophageal mucosal abnormalities (hyperkeratosis, dyskeratosis, cytonuclear abnormalities) in rats treated with N-nitrosobenzylmethylamine (NBMA). Retinol deficient rats fed with retinoïc acid (all-trans) show a mucosal ODC induction, but no morphological lesion. The association of retinoïc acid + retinol, as does retinol alone, prevents simultaneously histological lesions and enzymatic induction. In the liver of vitamin A deficient rats treated with NBMA, a stimulation of the ODC system, without any macroscopical lesions, has been observed.
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