These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Depolarizing effect of noradrenaline on neurons of the rat supraoptic nucleus in vitro.
    Author: Yamashita H, Inenaga K, Kannan H.
    Journal: Brain Res; 1987 Mar 10; 405(2):348-52. PubMed ID: 3567613.
    Abstract:
    Noradrenaline (NA) (1-100 microM) was applied to 41 neurons recorded intracellularly from the supraoptic nucleus (SON) of the rat hypothalamic slice preparation; 34 (83%) neurons showed membrane depolarization which was dose-dependent. The depolarization was frequently accompanied by decreased membrane resistance, increased firing rate and increased fluctuations in membrane potential. Following the application of the alpha-agonist, phenylephrine, 10 out of 11 neurons tested showed similar responses, while the beta-agonist, isoproterenol, caused no changes in 6 out of 7 SON cells. We found no difference in responsiveness between neurons having a 'phasic' or a 'non-phasic' pattern of firing. We conclude that NA depolarized and increased the firing rate of both vasopressin- and oxytocin-containing neurons through an action on alpha-adrenergic receptors.
    [Abstract] [Full Text] [Related] [New Search]